Publications by authors named "W W Leitner"
The chemical industry can now seize the opportunity to improve the sustainability of its processes by replacing fossil carbon sources with renewable alternatives such as CO, biomass, and plastics, thereby thinking ahead and having a look into the future. For their conversion to intermediate and final products, different types of catalysts-microbial, enzymatic, and organometallic-can be applied. The first part of this review shows how these catalysts can work separately in parallel, each route with unique requirements and advantages.
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- This study focuses on enhancing the process of electrohydrogenation for organic compounds, specifically aldehydes, using a nickel-bipyridine complex as a catalyst.
- The mechanism involves the aldehyde binding to the catalyst, forming a nickeloxirane intermediate, which then produces hydrogenation products through protonation.
- The researchers face challenges with the efficiency of proton transfers under electrocatalytic conditions and have investigated this through both experimental and computational approaches.
Methanolation of olefins is introduced as a new low-pressure synthetic pathway to C1 elongated alcohols. Formally, HCOH is added to the C=C bond in a 100 % atom efficient manner. Mechanistically, the overall transformation occurs as a tandem reaction sequence by combining the dehydrogenation of methanol to syngas at a CO : H ratio of 1 : 2 with subsequent hydroformylation to the corresponding aldehyde and its final hydrogenation to the alcohol.
View Article and Find Full Text PDFScreening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary human cells in high-throughput screening (HTS), leading to the discovery of a novel SM TLR7/8 agonist, PVP-037.
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