Publications by authors named "W W Kuebler"
Treatment with veno-venous extracorporeal membrane oxygenation (VV ECMO) has become a frequently considered rescue therapy in patients with severe acute respiratory distress syndrome (ARDS). Hemolysis is a common complication in patients treated with ECMO. Currently, it is unclear whether increased ECMO blood flow (Q̇) contributes to mortality and might be associated with increased hemolysis.
View Article and Find Full Text PDFCFTR as a therapeutic target for severe lung infection.
Am J Physiol Lung Cell Mol Physiol
January 2025
Lung infection is one of the leading causes of morbidity and mortality worldwide. Even with appropriate antibiotic and antiviral treatment, mortality in hospitalized patients often exceeds 10%, highlighting the need for the development of new therapeutic strategies. Of late, cystic fibrosis transmembrane conductance regulator (CFTR) is - in addition to its well-established roles in the lung airway and extrapulmonary organs - increasingly recognized as a key regulator of alveolar homeostasis and defense.
View Article and Find Full Text PDFArticle Synopsis
- Calcification in pulmonary hypertension associated with left heart disease appears to be influenced by the interaction between RUNX2 and TAZ, which are key regulators in osteogenic processes.
- Significant vascular calcification was observed in both patients and rat models, with elevated levels of RUNX2 and TAZ.
- Inhibiting TAZ or RUNX2 effectively reduced vascular calcification and the progression of pulmonary hypertension in the rat model, suggesting potential therapeutic targets.