Publications by authors named "W W J van de Sande"
Article Synopsis
- In a study of six EAPDC cases, histological features were similar to axial PDC, showing malignant cell characteristics, and genetic analysis revealed common loss of the SMARCB1 gene.
- Follow-up revealed significant clinical challenges, including local recurrences and metastasis within months of surgery, highlighting the aggressive nature and poor prognosis of these rare tumors.
Emerging therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease.
Lamis Yahia Mohamed Elkheir Pierre-Olivier Delaye Mélanie Penichon Kimberly Eadie Magdi Awadalla Mohamed Wendy Wilhelmina Johanna van de Sande
Eur J Med Chem
November 2024
Article Synopsis
- * Current treatments for eumycetoma, largely relying on antifungal drugs and surgery, have low success rates and high chances of relapse.
- * Researchers have synthesized 47 new chemical compounds that show better effectiveness and lower toxicity than existing treatments, particularly one compound that performed similarly to the standard drug itraconazole, suggesting they could be safer options for treating eumycetoma.
Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial.
Ahmed H Fahal Eiman Siddig Ahmed Sahar Mubarak Bakhiet Osama Elhadi Bakhiet Lamis Ahmed Fahal Wendy W J van de Sande
Lancet Infect Dis
November 2024
Background: Eumycetoma is an implantation mycosis characterised by a large subcutaneous mass in the extremities commonly caused by the fungus Madurella mycetomatis. Despite the long duration of treatment, commonly a minimum of 12 months, treatment failure is frequent and can lead to amputation. We aimed to compare the efficacy of two doses of fosravuconazole, a synthetic antifungal designed for use in onychomycosis and repurposed for mycetoma, with standard-of-care itraconazole, both in combination with surgery.
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