Publications by authors named "W W De Herder"
Article Synopsis
- - Midgut neuroendocrine tumors (NET) are linked to enterochromaffin cells and have shown a unique fecal microbial signature in patients, indicating an altered gut microbiome compared to healthy controls.
- - A study involving sequencing of fecal samples from 60 NET patients and 20 matched controls revealed specific differences in microbial communities, with 16 species and 18 pathways significantly varying between groups, yet no notable differences in microbial composition were found between patients with and without carcinoid syndrome (CS).
- - The research identifies potential microbial signatures that could serve as biomarkers for diagnosing midgut NET and distinguishing between patients with and without CS, with high accuracy in predicting presence based on microbial pathways and species.
Peptide receptor radionuclide therapy (PRRT) using [Lu-DOTA,Tyr]octreotate (Lu-DOTATATE) represents an established treatment modality for somatostatin receptor-positive, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumours (GEP NET) of grade 1 or 2. The studies have demonstrated that four cycles of PRRT with Lu-DOTATATE prolongs progression-free survival and preserves quality of life, in patients with grade 1 and 2 advanced GEP NET. Notably, first-line PRRT using Lu-DOTATATE in grade 2 and 3 GEP NET patients has also shown efficacy and safety.
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- Current research lacks clarity in distinguishing between primary ovarian neuroendocrine tumors (PON) and neuroendocrine ovarian metastases (NOM), prompting a study of patient data spanning 1991 to 2023, which identified 71 NOM and 17 PON cases.
- Analysis revealed that PON tumors are usually unilateral, often found in teratomas, while NOM are predominantly bilateral and not associated with teratomas.
- The findings suggest a need for different treatment approaches; unilateral PON within teratomas should be treated as PON, while PON without teratoma components show similarities to midgut NET metastases, requiring thorough imaging to check for hidden midgut NET.
Sidonia and Nicu de Barcsy: a famous mother with post-partum hirsutism after giving birth to a famous son with idiopathic short stature.
Endocrinol Diabetes Metab Case Rep
July 2024
Summary: At the end of the 19th century, an 18-year-old lady gave birth to a well-proportioned, though very small, son. After delivery, the mother developed a full-grown beard, whereas the son always remained of small stature. The mother developed diabetes mellitus and died, aged 59, from a complicated severe cold.
View Article and Find Full Text PDFNeuroendocrine tumors (NETs) are malignant neoplasms that can be associated with specific hormonal syndromes. We describe a novel syndrome of postmenopausal vaginal bleeding and ovarian estradiol overproduction due to ovarian NET localizations. An extensive workup was performed for 2 index patients with ovarian metastases of small bowel neuroendocrine tumors and symptoms of postmenopausal vaginal bleeding.
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