Publications by authors named "W Voss"
Background: Global longitudinal strain (GLS) has been used to identify patients at risk for cancer-therapy related cardiac dysfunction (CTRCD). However, there is limited data on the effectiveness of initiating cardioprotective therapy based on a strain-guided strategy in early stage HER2+ breast cancer patients. This randomized clinical trial assessed if treatment with carvedilol based on a strain-guided strategy can prevent development of CTRCD in HER2+ breast cancer patients on non-anthracycline based regimens.
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- The study analyzes the molecular composition of polyclonal IgG anti-spike antibodies from SARS-CoV-2 infection, vaccination, and their combination, termed "hybrid immunity."
- It finds that infection mainly triggers antibodies reactive to the spike S2 and N-terminal domain, while vaccination predominantly induces antibodies that target the receptor-binding domain (RBD).
- The research also shows how original IgG antibodies can enhance their effectiveness against SARS-CoV-2 variants after subsequent exposures, highlighted by the SC27 antibody's improved neutralization capabilities and binding affinity.
Unlabelled: We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with >60% of the ensuing serological response originating from the initial antibodies generated during the first exposure.
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- * A new platform called Spike Display has been developed to quickly analyze variations in spike proteins from over 200 SARS-CoV-2 variants in terms of their functionality, including how well they bind to receptors and how they're recognized by antibodies.
- * The study identified critical mutations in variants that affect spike protein expression and their ability to evade neutralizing antibodies, suggesting that Spike Display could enhance the development of better vaccines and therapies against SARS-CoV-2 and similar viruses.