Publications by authors named "W Verbiest"
Article Synopsis
- African bistable savannas are rich in biodiversity and require conservation efforts.
- Forest restoration through natural regeneration, rather than human intervention like burning or planting, can enhance biodiversity and carbon stocks.
- The decision to restore forests or protect savannas should be based on a deep understanding of the local environment and its specific needs.
Article Synopsis
- A significant portion of potential global forest restoration lies in unstable mesic savannas in Africa, which can enhance carbon and biodiversity if protected from human-induced fires.
- A study in the Democratic Republic of the Congo found that aboveground carbon recovery in an 88-ha savanna patch took about 17 years, with a long-term estimate suggesting up to 112 years to reach near old-growth forest carbon levels.
- While species richness improved to 33.17% after 17 years, achieving full recovery of both species richness and composition may take 54 and 124 years, respectively, highlighting the need for ongoing monitoring and consideration of socio-economic and climate variability.
Objective: To assess the prevalence of modest (< 10-fold) decreases in baseline non-nucleoside reverse transcriptase inhibitor (NNRTI) susceptibility and their impact on virological response to NNRTI-containing triple therapy in drug-naive individuals.
Methods: Baseline HIV resistance phenotype, genotype and response to therapy were examined retrospectively for all antiretroviral-naive individuals initiating therapy with two nucleoside analogues and an NNRTI in British Columbia, Canada, between 05/1997 and 08/1999 (n = 279), followed until July 31 2001. Time to viral suppression (first of at least two consecutive plasma viral loads < 400 copies HIV RNA copies/ml) and viral rebound (to > or = 400 copies/ml after first pVL < 400 copies HIV RNA copies/ml), were estimated by Kaplan-Meier methods.
Background: To determine the impact of HIV-1 drug resistance at baseline and antiretroviral drug levels (DL) during follow-up on virologic response to the next antiretroviral regimen.
Methods: Baseline genotypic and phenotypic susceptibility was obtained for plasma virus from patients failing a protease inhibitor-containing regimen. Untimed plasma antiretroviral DL were performed and the distribution of DL after 12 weeks of follow-up was classified as above (DLHigh) or below (DLLow) the median.
Objective: To compare the effect of treatment decisions guided by phenotypic resistance testing (PRT) or standard of care (SOC) on short-term virological response.
Design: A prospective, randomized, controlled clinical trial conducted in 25 university and private practice centers in the United States.
Participants: A total of 272 subjects who failed to achieve or maintain virological suppression (HIV-1-RNA plasma level > 2000 copies/ml) with previous exposure to two or more nucleoside reverse transcriptase inhibitors and one protease inhibitor.