Automated segmentation of the sacro-iliac joints, posterior spinal joints and discovertebral units on low-dose computed tomography for Na[F]F PET lesion detection in spondyloarthritis patients.

Purpose: Spondyloarthritis (SpA) is a chronic inflammatory rheumatic disease which involves the axial skeleton. Quantitative sodium fluoride-18 (Na[F]F) PET/CT is a new imaging approach promising for accurate diagnosis and treatment monitoring by assessment of molecular bone pathology in SpA. Detection of Na[F]F PET positive lesions is time-consuming and subjective, and can be replaced by automatic methods.

OTULIN Haploinsufficiency-Related Fasciitis and Skin Necrosis Treated by TNF Inhibition.

Here, we describe an adult female with severe fasciitis and skin necrosis who carried a private, predicted deleterious missense mutation in OTULIN in heterozygosity. OTULIN is a cellular regulator of deubiquitination that has been shown to play a key role in intrinsic immunity against staphylococcal α-toxin. The patient was treated with broad-spectrum antibiotics, and multiple surgical explorations were conducted without clinical response.

Identification of drug candidates targeting monocyte reprogramming in people living with HIV.

Introduction: People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for application to larger cohorts, we compared multiple omics data layers.

Methods: Bulk and single-cell transcriptomics, flow cytometry, proteomics, chromatin landscape analysis by ATAC-seq as well as drug stimulation were performed in a small number of blood samples derived from PLHIV and healthy controls from the 200-HIV cohort study.