Publications by authors named "W Valdar"
Coronaviruses have caused three severe epidemics since the start of the 21 century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of factors leading to severe coronavirus disease. We screened ten strains from the Collaborative Cross mouse genetic reference panel and identified strains CC006/TauUnc (CC006) and CC044/Unc (CC044) as coronavirus-susceptible and resistant, respectively, as indicated by variable weight loss and lung congestion scores four days post-infection.
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- Emerging evidence suggests that liver disease may begin in development due to high genome plasticity and the establishment of liver function pathways.
- A study using a Collaborative Cross mouse model with developmental vitamin D deficiency (DVD) explored how DVD disrupts liver gene expression and metabolism, factoring in the impact of parental origin of the genome (POG).
- Results showed that DVD significantly affected liver gene expression, reducing genes related to liver development and energy production, with distinct responses observed between different POGs, particularly in gene expression and metabolic profiles related to energy utilization.
Background: The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized Collaborative Cross strain CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, in contrast to C3H/HeJ (C3H) mice.
Objective: This study aimed to determine the genetic basis of orally induced anaphylaxis to peanut in CC027 mice.
Background: The gut microbiota is modulated by a combination of diet, host genetics, and sex effects. The magnitude of these effects and interactions among them is important to understanding inter-individual variability in gut microbiota. In a previous study, mouse strain-specific responses to American and ketogenic diets were observed along with several QTLs for metabolic traits.
View Article and Find Full Text PDFBackground: The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice.
Objective: To determine the genetic basis of orally-induced anaphylaxis to peanut in CC027 mice.