Publications by authors named "W Vainchenker"
Elevated circulating levels of calprotectin (CAL), the S100A8/A9 heterodimer, are biomarkers of severe systemic inflammation. Here, we investigate the effects of CAL on early human hematopoiesis. CAL demonstrates limited impact on gene expression in stem and progenitor cells, in contrast with interleukin-6 (IL6), which promotes the expression of the and genes in hematopoietic progenitors and the generation of monocytes that release CAL.
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- Oxazolidinones, like linezolid and tedizolid, can cause adverse reactions, particularly thrombocytopenia, due to their impact on mitochondrial function, though the exact mechanism is still unclear.
- * In experiments with human CD34+ cells, oxazolidinones significantly reduced burst-forming unit-erythroid (BFU-E) colony formation and disrupted the differentiation of megakaryocytes, affecting their typical maturation and structure.
- * The toxicity observed was more severe with tedizolid compared to linezolid, suggesting that mitochondrial dysfunction plays a crucial role in thrombocytopenia, which complicates potential pharmacological solutions for this side effect.
Article Synopsis
- Mutations in a protein called calreticulin (mutCALR) cause blood disorders known as myeloproliferative neoplasms (MPNs), but there aren’t any treatments specifically targeting this mutation.
- A new antibody called INCA033989 can specifically attack cells with the mutCALR mutation, stopping them from growing and causing problems.
- In tests on mice, INCA033989 not only prevented issues like high blood cell counts but also showed it could help treat the disease without harming normal blood cell production.
Myeloproliferative neoplasms (MPN) are blood cancers that appear after acquiring a driver mutation in a hematopoietic stem cell. These hematological malignancies result in the overproduction of mature blood cells and, if not treated, induce a risk of cardiovascular events and thrombosis. Pegylated IFN$\alpha $ is commonly used to treat MPN, but no clear guidelines exist concerning the dose prescribed to patients.
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