The organisers of this month's HefmA 2014 annual conference and exhibition promise delegates "the opportunity to hear international perspectives on the current issues facing the worldwide 'family' of health estates and facilities professionals". Conference speakers will include a US-based consultant architect discussing 'a transformational change programme which has achieved up to threefold greater throughput using the existing footprint in a US Emergency Department'; the assistant director, Facilities Services, at Health Facilities Scotland, focusing on HFS's work to ensure high training standards and succession planning, former BBC war correspondent, Kate Adie, describing some of the 'extraordinary experiences' of an eventful career, and Will Whitehorn, a former search-and-rescue helicopter crewman, who later became president of 'the world's first commercial spaceline', Virgin Galactic, giving his view on technology's impact in business.
View Article and Find Full Text PDFCanrenone, a metabolic product of spironolactone, which competes with ouabain for binding to Na-K-ATPase at the digitalis receptor site and by itself inhibits Na-K-ATPase, was administered intramuscularly to reduced renal mass-saline drinking hypertensive and reduced renal mass-distilled water drinking normotensive rats for 8 days. Reduced renal mass-saline hypertension in the rat, is a low renin, volume expanded form of hypertension. Rats with this type of hypertension have been shown to have depressed arterial Na-K pump activity and increased Na-K pump inhibitory activity in their plasma.
View Article and Find Full Text PDFWe have previously shown that a 10-min intravenous infusion of 6-iodo-amiloride, an analogue of the sodium channel blocker amiloride, causes a sustained decrease in blood pressure in two genetic models of hypertension, spontaneously hypertensive rats (SHR) and Dahl salt-sensitive (DS) rats. In contrast, the same infusion produced only a transient decrease in blood pressure in two renal models of hypertension, viz. one-kidney, one clip, and reduced renal mass-saline rats.
View Article and Find Full Text PDF