A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models arising from biology.

Practical identifiability is a critical concern in data-driven modeling of mathematical systems. In this paper, we propose a novel framework for practical identifiability analysis to evaluate parameter identifiability in mathematical models of biological systems. Starting with a rigorous mathematical definition of practical identifiability, we demonstrate its equivalence to the invertibility of the Fisher Information Matrix.

Organic/Inorganic Hybrid Cross-Linked Gel Polymer Electrolyte for Optimizing the Solvation Structure of Lithium Ions.

Lithium metal electrodes inevitably lead to the decomposition of the liquid electrolyte and lithium dendrite growth, both of which result in the formation of unstable solid electrolyte intermediates (SEIs). Gel polymer electrolytes (GPEs) are expected to replace liquid electrolytes for optimizing the SEI issues of lithium metal. Herein, a cellulose-based gel electrolyte cross-linked by thiol-modified polyhedral oligomeric silsesquioxane (thiol-modified-POSS) was successfully obtained based on "thiol-ene" click chemistry.

Intravenous lidocaine decreased oxygen-desaturation episodes induced by propofol-based sedation for gastrointestinal endoscopy procedures: a prospective, randomized, controlled trial.

Background: As a popularly used analgesic adjuvant, intravenous (IV) lidocaine could reduce the consumption of propofol in painless gastrointestinal (GI) endoscopy. However, whether IV lidocaine could affect the incidence of oxygen-desaturation episodes (ODE) during painless GI endoscopy is still unknown. Therefore, we tested the hypothesis that IV lidocaine could decrease the incidence of propofol-induced ODE and involuntary movements in patients during GI endoscopy.

Calcified chondroid mesenchymal neoplasm: a clinicopathological and molecular analysis.

Aims: Calcified chondroid mesenchymal neoplasm (CCMN) is a recently identified category of soft tissue neoplasms defined by cartilage or cartilaginous matrix formation and gene fusions. Its rarity and similarities to other soft tissue tumours pose diagnostic challenges. This study aims to deepen understanding of CCMN, highlighting molecular pathology's role in diagnosis to reduce misdiagnosis, overdiagnosis and overtreatment.

Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axis.

Glucagon has recently been found to modulate liver fat content, in addition to its role in regulating gluconeogenesis. However, the precise mechanisms by which glucagon signaling synchronizes glucose and lipid metabolism in the liver remain poorly understood. By employing chemical and genetic approaches, we demonstrate that inhibiting the androgen receptor (AR) impairs the ability of glucagon to stimulate gluconeogenesis and lipid catabolism in primary hepatocytes and female mice.