Exosomes of stem cells: a potential frontier in the treatment of osteoarthritis.

The aging population has led to a global issue of osteoarthritis (OA), which not only impacts the quality of life for patients but also poses a significant economic burden on society. While biotherapy offers hope for OA treatment, currently available treatments are unable to delay or prevent the onset or progression of OA. Recent studies have shown that as nanoscale bioactive substances that mediate cell communication, exosomes from stem cell sources have led to some breakthroughs in the treatment of OA and have important clinical significance.

A Potent Antibacterial Peptide (P6) from the De Novo Transcriptome of the Microalga .

Marine microalgae are a rich source of natural products, and their amino acid-based antimicrobial agents are usually obtained by enzymatic hydrolysis, which is inefficient and limits the research on antimicrobial peptides (AMPs) from microalgae. In this study, is used as a model to predict antimicrobial peptides through high-throughput methods, and 471 putative peptides are identified based on the de novo transcriptome technique. Among them, three short peptides, P1, P6, and P7 were found to have antimicrobial activity against , , , and yeast , and they showed no hemolytic activity even at higher concentrations up to 10 mg/mL.

Discovery of the salicylaldehyde-based compound DDO-02267 as a lysine-targeting covalent inhibitor of ALKBH5.

N-methyladenosine (mA) is a crucial mRNA epigenetic modification in eukaryotes, and its methylation regulation is associated with the proliferation and metastasis of diverse tumor cells. ALKBH5 functions as a demethylase for mA and plays a role in the demethylation process, thus influencing tumor cell growth and migration. However, there are limited reports on selective small molecule inhibitors of ALKBH5.

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis.

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases.

[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)].

Tongkat Ali(Eurycoma longifolia Jack.) is a medicinal plant of Simaroubaceae in Southeast Asia, with centuries of medicinal history. Rich clinical and pharmacological research results have been attained for this plant, which demonstrates diverse and definite effects and high safety, showcasing advantages and broad market prospects to be introduced as a new medicinal plant.