Publications by authors named "W Tse"
Objectives: To compare the ability to perform basic life support (BLS) skills on children and infants in a moving ambulance whether or not they are properly secured to the stretcher.
Methods: Emergency Medicine Services provider ability to perform BLS skills was measured in moving ambulances on a closed course using an analog for child and infant cardiac arrest. Data were compared for child and infant manikins secured to the stretcher via different methods in simulated patient resuscitations performed by 24 participants.
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanisms and cellular responses remain poorly understood. In this work, we report that deficiency of ubiquitin-specific protease 39 (USP39) in human cell lines, zebrafish larvae, and mice led to impaired spliceosome assembly and a cytotoxic splicing profile characterized by the use of cryptic 5' splice sites.
View Article and Find Full Text PDFBackground: Advances in haemolytic disease of the fetus and newborn have led to numerous treatment options. We report practice variations in the management and outcomes of haemolytic disease of the fetus and newborn in at-risk pregnancies.
Methods: In this international, retrospective, observational cohort study, data from cases with moderate or severe haemolytic disease of the fetus and newborn were retrieved from 31 centres in 22 countries.
Article Synopsis
- - The Daya Bay experiment has successfully measured the oscillation amplitude and frequency of reactor antineutrinos over nearly 2,000 days of data, finding significant results about their behavior.
- - They observed over 3.6 million signal candidates using improved selection and calibration methods, leading to a measurement of sin²2θ₁₃ = 0.0759 with a precision that indicates how antineutrinos change states.
- - Combining results from different detection methods at Daya Bay, the overall measurement of sin²2θ₁₃ increased precision to 0.0833±0.0022, representing an 8% improvement in understanding these neutrino properties.
Article Synopsis
- * A machine learning approach was utilized to analyze LNP characteristics, focusing on aspects like size, zeta potential, and placental transport efficiency using various LNP formulations and in vitro models.
- * The optimized LNP formulations demonstrated minimal toxicity and significantly improved transport rates by 622%, while adjustments in lipid composition enhanced specific gene delivery to fetal lungs.