Publications by authors named "W Traboulsi"
Tumor development necessitates immune escape through different mechanisms. To counteract these effects, the development of therapies targeting Immune Checkpoints (ICP) has generated interest as they have produced lasting objective responses in patients with advanced metastatic tumors. However, many tumors do not respond to inhibitors of ICP, necessitating to further study the underlying mechanisms of exhaustion.
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- Normal fetal growth and placental development require active blood vessel formation (angiogenesis) at the mother-baby interface during pregnancy.
- Researchers have developed a new, noninvasive method to measure placental blood vessel growth in pregnant mice using a fluorescent molecule, Angiostamp700, that targets specific proteins found in developing blood vessels.
- This method allows for the quantification of angiogenic activity and provides insights into pregnancy outcomes without harming the mother or fetus.
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- Gestational trophoblastic diseases (GTD) include rare tumors related to pregnancy, with gestational choriocarcinoma (CC) being a highly aggressive type that can lead to high mortality if not treated quickly.
- CC has a higher incidence in molar pregnancies and poses greater risks in developing countries, with rates as high as 20 cases per 1,000 pregnancies.
- A new animal model for CC was created by injecting specific cancer cells into the placenta of pregnant mice, allowing researchers to mimic cancer development and metastasis, which highlights the role of placental blood vessels in spreading the tumor.
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- Glioblastoma multiforme (GBM) is a serious brain tumor that often doesn't respond well to treatments, like the anti-VEGF medicine called bevacizumab.
- Researchers found that a substance called sCD146 in blood can help predict how well patients will do on bevacizumab, with higher levels meaning worse outcomes.
- Combining bevacizumab with a new medicine called mucizumab could be a better way to fight this type of brain cancer and stop it from getting worse.
Article Synopsis
- The study investigates the role of soluble CD146 (sCD146) and its interaction with galectin-1 (Gal1) in pregnancy complications, particularly focusing on placenta-related issues.
- Researchers conducted experiments involving 115 women divided into healthy, normal pregnancy, and pregnancy complication groups to analyze trophoblast migration and measure levels of sCD146 and Gal1.
- Results indicated that lower sCD146 and higher Gal1 levels are present in normal pregnancies, while elevated sCD146 in preeclampsia patients suggests that sCD146 could serve as a biomarker and a possible therapeutic target for such complications.