Publications by authors named "W Thomas Mueller"

Objectives: Opioid-associated fatal and non-fatal overdose rates continue to rise. Prehospital overdose education and naloxone distribution (OEND) programs are attractive harm-reduction strategies, as patients who are not transported by EMS after receiving naloxone have limited access to other interventions. This narrative summary describes our experiences with prehospital implementation of evidence-based OEND practices across Ohio as part of the HEALing Communities Study (HCS).

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Objectives: According to the International Agency for Research on Cancer, styrene is probably carcinogenic for lymphohaematopoietic neoplasms, with insufficient evidence for other cancer sites. We compared mortality and cancer incidence (for the first time) in a UK cohort occupationally exposed to high levels of styrene to that of the general population of England and Wales.

Methods: The follow-up for mortality ran from 1969 to 2022, while the follow-up for cancer incidence ran from 1971 to 2020.

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Biological clocks and other molecular biomarkers of aging are difficult to implement widely in a clinical setting. In this study, we used routinely collected hematological markers to develop an aging clock to predict blood age and determine whether the difference between predicted age and chronologic age (aging gap) is associated with advanced aging in mice. Data from 2,562 mice of both sexes and three strains were drawn from two longitudinal studies of aging.

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Article Synopsis
  • Glioblastoma multiforme (GBM) is the most aggressive brain tumor but rarely spreads outside the central nervous system, with only 0.4% of cases showing metastasis, possibly influenced by genetic mutations.
  • A systematic review analyzed 357 studies and 211 patients, revealing that 36.9% of metastases were found near surgical sites and common metastasis locations included bone, lung, and lymph nodes.
  • Unique genetic mutations were observed in primary GBM and metastatic lesions, suggesting that understanding these changes could explain how GBMs spread beyond the CNS and aid future treatment strategies.
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The IMPRoving Exposure aSSessment Methodologies for Epidemiological Studies on Pesticides (IMPRESS) project (http://www.impress-project.org/) aimed to further the understanding of the performance of pesticide exposure assessment methods (EAMs).

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