Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia.

Supervised Injectable Opioid Treatment (SIOT) targets people experiencing opioid dependence who have not benefited from existing treatments. In this population, SIOT has been demonstrated to be efficacious and effective, yet this modality of treatment has only been taken up in a few countries. In this commentary we describe the socio-political context and history to the recent establishment of an implementation trial of injectable hydromorphone in Sydney, Australia.

Multi-study feasibility analysis on a composite biomarker of inflammatory resilience to quantify the effects of energy restriction on low-grade inflammation in overweight and obese individuals.

Purpose: Assessing the health impacts of nutritional interventions in metabolically compromised but otherwise healthy individuals is challenging, necessitating sensitive tools. Phenotypic flexibility offers an innovative way to measure homeostatic capacity during challenge tests. A composite biomarker of inflammatory resilience has proven useful in evaluating the health benefits of whole-grain wheat interventions in overweight and obese individuals.

Improved Fetal Magnetic Resonance Imaging Using a Flexible Metasurface.

Recent advancements in magnetic resonance imaging (MRI) techniques are promising for the detection of fetal abnormalities, and MRI may supplement or replace prenatal ultrasound scans in the future. In particular, the interest of scientific and medical communities in high-field (3T) MRI continues to grow due to its improved contrast-to-noise and signal-to-noise ratios compared to clinical MRI of lower field strength (1.5T).

Ethnic differences in efficacy of drug treatment in patients with an acute manic episode: an individual patient data meta-analysis of randomized placebo-controlled trials.

Background: Little is known about the effect of ethnicity on drug treatment in patients with an acute manic episode. The aim of this study is to determine whether ethnicity moderates the response to drug treatment in patients with an acute manic episode, and whether this moderation is independent of potential confounders.

Methods: We analysed ten short-term placebo-controlled registration trials of atypical antipsychotics and anticonvulsive mood stabilizers in patients with an acute manic episode (n = 2199).

Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers.

Digital biomarkers are quantifiable and objective indicators of a person's physiological function, behavioral state or treatment response, that can be captured using connected sensor technologies such as wearable devices and mobile apps. We envision that continuous and 24-h monitoring of the underlying physiological and behavioral processes through digital biomarkers can enhance early diagnostics, disease management, and self-care of cardiometabolic diseases. Cardiometabolic diseases, which include a combination of cardiovascular and metabolic disorders, represent an emerging global health threat.