Publications by authors named "W T Randazzo"
Gastroenteritis and hepatitis are the most common illnesses resulting from the consumption of food contaminated with human enteric viruses. Several natural compounds have demonstrated antiviral activity against human enteric viruses, such as human norovirus and hepatitis A virus, while little information is available for hepatitis E virus. Many in-vitro studies have evaluated the efficacy of different natural compounds against human enteric viruses or their surrogates.
View Article and Find Full Text PDFCold plasma is a promising alternative for water treatment owing to pathogen control and a plethora of issues in the agriculture and food sectors. Shellfish pose a serious risk to public health and are linked to large viral and bacterial outbreaks. Hence, current European regulations mandate a depuration step for shellfish on the basis of their geographical growth area.
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- Fecal-orally transmitted gastroenteritis viruses, especially human noroviruses, are a major public health issue linked to contaminated water, but their infectivity has been hard to measure in lab settings.
- This study tested the human intestinal enteroids (HIE) model to evaluate the infectivity of various gastroenteritis viruses in wastewater, finding that this method efficiently supported viral replication without needing complex sample handling.
- Of the 28 wastewater samples tested, 57% showed viral replication, with multiple viral types coexisting in some samples, demonstrating the HIE model's effectiveness in identifying infectious gastroenteritis viruses in real-world wastewater.
Article Synopsis
- This study investigates the effectiveness of different disinfectants, including free chlorine, chlorine dioxide, and peracetic acid, in reducing viruses in produce wash water to enhance food safety against human norovirus outbreaks.
- Results revealed that free chlorine was highly effective, inactivating over 8 logs of human norovirus in just 1 minute, while chlorine dioxide and peracetic acid had variable success.
- The research also introduces a predictive model for virus inactivation that can help optimize post-harvest safety protocols in the fresh produce industry.
Rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in children under 5 years old worldwide, and several studies have demonstrated that histo-blood group antigens (HBGAs) play a role in its infection process. In the present study, human stool filtrates from patients diagnosed with RV diarrhea (genotyped as P[8]) were used to infect differentiated Caco-2 cells (dCaco-2) to determine whether such viral strains of clinical origin had the ability to replicate in cell cultures displaying HBGAs. The cell culture-adapted human RV Wa model strain (P[8] genotype) was used as a control.
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