Business Intent and Network Slicing Correlation Dataset from Data-Driven Perspective.

Intent-Based Networking (IBN) is an emerging network management technology that enables automated configurations based on user intents. A critical aspect of IBN is the accurate and autonomous extraction of user intents and their translation into a language comprehensible by network management systems. However, the current scarcity of publicly available datasets for intent extraction presents significant challenges.

PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies.

C-MYC is a proto-oncoprotein whose dysregulation triggers tumorigenesis and tumor progression in ≈70% of cancer cases. It is presently demonstrated that aberrantly upregulated MYC is caused by the overexpressed and "extra-nucleolar" PDCD11 in p53-mutant breast and colon cancer cells, which is highly correlated to tumor progression, metastasis, and recurrence. In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E3 ligase components targeting C-MYC, from interacting with and ubiquitinating C-MYC in feedback.

Highly Fused Lindenane Sesquiterpenoid Dimers with Apoptosis-Inducing Properties from var. .

Six undescribed lindenane sesquiterpenoid dimers (LSDs), shimianolides A-F (-), were isolated from the whole plants of var. . Shimianolides A-C (-) represent an unprecedented class of LSDs, distinguished by a highly fused 3/5/6/6/6/5/6/6/5/3 decacyclic scaffold.

Surfactant-induced hole concentration enhancement for highly efficient perovskite light-emitting diodes.

It is widely acknowledged that constructing small injection barriers for balanced electron and hole injections is essential for light-emitting diodes (LEDs). However, in highly efficient LEDs based on metal halide perovskites, a seemingly large hole injection barrier is usually observed. Here we rationalize this high efficiency through a surfactant-induced effect where the hole concentration at the perovskite surface is enhanced to enable sufficient bimolecular recombination pathways with injected electrons.

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents.

Background: The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2 and elucidating their potential evolutionary pathways are essential for battling the coronavirus disease 2019 (COVID-19) pandemic.

Methods: Broadly neutralizing antibodies were isolated using single cell sorting from three COVID-19 convalescents infected with prototype SARS-CoV-2 strain.