Publications by authors named "W T Ambrosius"
The Systolic Blood Pressure Intervention Trial (SPRINT) estimated the effect of intensive SBP treatment (target <120 mmHg) compared to standard (<140 mmHg) on the risk of cardiovascular events in adults aged 50+ years. Clinical trial participants may differ from an intervention's target population. We generalized the SPRINT results to U.
View Article and Find Full Text PDFResearch articles in the clinical and translational science literature commonly use quantitative data to inform evaluation of interventions, learn about the etiology of disease, or develop methods for diagnostic testing or risk prediction of future events. The peer review process must evaluate the methodology used therein, including use of quantitative statistical methods. In this manuscript, we provide guidance for peer reviewers tasked with assessing quantitative methodology, intended to complement guidelines and recommendations that exist for manuscript authors.
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- * The study will include 212 participants with PAD and a BMI of 25 or higher, who will be randomized to receive either a behavioral weight loss intervention (via group sessions, a smartphone app, and phone coaching) or to focus solely on walking exercise.
- * Key outcomes will measure improvements in walking distance after 12 months, alongside other physical activity metrics, dietary quality, and muscle health, ultimately seeking to enhance the treatment approach for PAD patients who are also overweight or obese.
Objective: Over the last few decades clinicians have become aware that cognitive impairment might be a major cause of disability, loss of employment and poor quality of life in patients suffering from multiple sclerosis [MS].The impact of disease modifying therapies [DMTs] on cognition is still a matter of debate. Theoretically, DMTs could exert a substantial beneficial effect by means of reducing neuroinflammation and brain atrophy, which are established correlates of cognitive dysfunction.
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- The text discusses the evolving role of collaborative biostatistics units in academic health centers (AHCs) across the U.S., which provide centralized resources and infrastructure for researchers in various fields or within specific disciplines like cancer.
- A survey of 129 leaders revealed that most are over 45, hold doctoral degrees, and typically have primary appointments in medical schools, with key metrics for career advancement including NIH grant funding and authorship in peer-reviewed journals.
- The findings offer a benchmark for evaluating collaboration models, serving as a useful reference for institutional administrators looking to enhance or restructure quantitative support infrastructures.