Publications by authors named "W Stephen Aldridge Iii"
Introduction: Elevated levels of behavioral inhibition (BI) may connote risk for both anxiety and substance use disorders. BI has consistently been shown to be associated with increased levels of anxiety, while the association between BI and substance use has been mixed. It is possible that the relationship between BI and substance use varies by individual difference factors.
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- - The PS modification increases the stability and protein binding of gapmer antisense oligonucleotides (ASOs) while allowing RNaseH1 activity; researchers tested the impact of adding mesyl-phosphoramidate (MsPA) linkages on various ASO properties.
- - Although substituting PS with MsPA didn’t compromise chemical stability or RNA affinity, it did reduce the overall activity of ASOs; however, certain substitutions were shown to minimize immune response and toxicity in cells and mice.
- - The combination of PS and MsPA linkages presents a promising new platform for developing ASO drugs that are more potent, have a better safety profile, and maintain their effectiveness for longer periods, similar to enhanced si
Harmful algal blooms (HABs), varying in intensity and causative species, have historically occurred throughout the Chesapeake Bay, U.S.; however, phycotoxin data are sparse.
View Article and Find Full Text PDFTwo oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum® Clinformatics® Data Mart database.
View Article and Find Full Text PDFObjective: To evaluate the electrochemical properties, biological response, and surface characterization of an electrodeposited Platinum-Iridium (Pt-Ir) electrode coating on cochlear implants subjected to chronic stimulation in vivo.
Approach: Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), charge injection limit (CIL), and voltage transient (VT) impedance were measured bench-top before and after implant and in vivo. Coated Pt-Ir and uncoated Pt electrode arrays were implanted into cochlea of normal hearing rats and stimulated for ∼4 h d, 5 d week for 5 weeks at levels within the normal clinical range.