Publications by authors named "W Shan Siah"
Article Synopsis
- The study investigates how limbic networks are affected in individuals with Amyotrophic Lateral Sclerosis (ALS), particularly focusing on emotional and cognitive deficits.
- It involved 204 ALS patients and 111 healthy controls, using advanced imaging techniques to analyze specific brain regions associated with memory and emotion.
- Results showed significant atrophy in key brain areas of ALS patients, regardless of genetic factors, emphasizing the need for thorough neuropsychological assessments in ALS diagnosis and treatment.
Chrononutrition, an emerging body of evidence on the relationship between biological rhythms and metabolism, has been established to be associated with glycemic responses. However, the available evidence is inconsistent, due to protocol variations. Therefore, this review aims to summarize the findings on chrononutrition characteristics and their association with glycemic responses among adults.
View Article and Find Full Text PDFIntroduction: Pseudobulbar affect (PBA) is a distressing symptom of a multitude of neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular and neurodegenerative conditions. It manifests in disproportionate emotional responses to minimal or no contextual stimulus. It has considerable quality of life implications and treatment can be challenging.
View Article and Find Full Text PDFBackground: Bulbar dysfunction is a cardinal feature of ALS with important quality of life and management implications. The objective of this study is the longitudinal evaluation of a large panel imaging metrics pertaining to bulbar dysfunction, encompassing cortical measures, structural and functional cortico-medullary connectivity indices and brainstem metrics.
Methods: A standardised, multimodal imaging protocol was implemented with clinical and genetic profiling to systematically appraise the biomarker potential of specific metrics.
Background And Purpose: Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder associated with considerable clinical disability. Symptoms are typically exclusively linked to primary motor cortex degeneration and the contribution of pre-motor, supplementary motor, cortico-medullary and inter-hemispheric connectivity alterations are less well characterized.
Methods: In a single-centre, prospective, longitudinal neuroimaging study 41 patients with PLS were investigated.