Publications by authors named "W Sewell"
Introduction: Flow cytometry (FCM) is widely used in the diagnosis of mature B-cell neoplasms (MBN), and FCM data are usually consistent with morphological findings. However, diffuse large B-cell lymphoma (DLBCL), a common MBN, is sometimes not detected by FCM. This study aimed to explore factors that increase the likelihood of failure to detect DLBCL by FCM.
View Article and Find Full Text PDFCorrection: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
Leukemia
September 2023
Article Synopsis
- Heterozygous mutations in PIK3R1 cause activated PI3Kδ syndrome 2 (APDS2), which shares symptoms with APDS1 caused by PIK3CD mutations.
- Research using a CRISPR/Cas9 mouse model and patient immune cells revealed that PIK3R1 mutations lead to unique cellular defects, including issues with B cell function and survival of pups.
- The study found important differences in how PIK3R1 loss-of-function (LOF) and PIK3CD gain-of-function (GOF) mutations affect immune cell signaling and function, highlighting distinct genetic impacts on immune health.
Background: Central compartment atopic disease (CCAD) and eosinophilic chronic rhinosinusitis (eCRS) are two clinical phenotypes of primary diffuse type 2 chronic rhinosinusitis (CRS) defined in the European Position Paper on Rhinosinusitis 2020 classification. Currently, the distinction between these subtypes relies on phenotypic features alone.
Objective: This study aimed to investigate whether eosinophil activation differed between CCAD and eCRS.