Biopolymer Hydrogel Scaffolds Containing Doxorubicin as A Localized Drug Delivery System for Inhibiting Lung Cancer Cell Proliferation.

A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy.

The effect of trochleoplasty on patellar stability and kinematics: a biomechanical study in vitro.

Objective patellar instability has been correlated with dysplasia of the femoral trochlea. This in vitro study tested the hypothesis that trochleoplasty would increase patellar stability and normalise the kinematics of a knee with a dysplastic trochlea. Six fresh-frozen knees were loaded via the heads of the quadriceps.

Patellofemoral kinematics during knee flexion-extension: an in vitro study.

The purpose of this work was to obtain kinematics data for the normal human patellofemoral joint in vitro. Eight fresh-frozen cadaver knees were used. The heads of the quadriceps were separated, and the knees mounted in a kinematics rig.

Biomechanics of patellofemoral joint prostheses.

We describe the biomechanics of the patellofemoral joint and of patellofemoral joint prostheses. It seemed that the designs and associated instruments that were studied had little research and development and that soft tissue realignment procedures often were needed because of pre-existing pathology. Factors that help these unicompartmental implants to integrate with the surrounding knee structures are discussed, particularly articular geometry, contact areas, forces and fixation.