Publications by authors named "W Sebastian Doherty-Boyd"
Article Synopsis
- Scientists are working on using special types of stem cells called Long-term reconstituting haematopoietic stem cells (LT-HSCs) to help treat blood problems through transplants.
- One challenge is that LT-HSCs are hard to find and don’t live long in lab conditions, but researchers have made progress in keeping them alive using special support systems.
- They created a new game-changing environment using soft materials that help these LT-HSCs survive and even support gene editing, which could improve treatment for blood disorders!
The bone marrow (BM) niche is a complex microenvironment that provides the signals required for regulation of hematopoietic stem cells (HSCs) and the process of hematopoiesis they are responsible for. Bioengineered models of the BM niche incorporate various elements of the in vivo BM microenvironment, including cellular components, soluble factors, a three-dimensional environment, mechanical stimulation of included cells, and perfusion. Recent advances in the bioengineering field have resulted in a spate of new models that shed light on BM function and are approaching precise imitation of the BM niche.
View Article and Find Full Text PDFHematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and immune cells. They reside primarily within the bone marrow (BM) niche microenvironment, which provides signals responsible for the regulation of HSC activities. While our understanding of these signalling mechanisms continues to improve, our ability to recapitulate them in vitro to harness the clinical potential of the HSC populations is still lacking.
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