Designed protein aggregates entrapping carbon nanotubes for bioelectrochemical oxygen reduction.

The engineering of robust protein/nanomaterial interfaces is critical in the development of bioelectrocatalytic systems. We have used computational protein design to identify two amino acid mutations in the small laccase protein (SLAC) from Streptomyces coelicolor to introduce new inter-protein disulfide bonds. The new dimeric interface introduced by these disulfide bonds in combination with the natural trimeric structure drive the self-assembly of SLAC into functional aggregates.

The effect of etofibrate retard, bezafibrate and procetofen.

The effects and side effects of 500 mg of etofibrate retard were comared with those of 100 mg t.i.d.

Frequently used lipid-lowering drugs having no guaranteed effect.

The therapeutic value of frequently used lipid-lowering agents such as the essential phospholipids (EPL), pyridoxal-phosphate (PP) and cynarin as well as the use of chenodeoxycholic acid and disaccharidase inhibitors in the treatment of various forms of hyperlipoproteinaemia is discussed critically. In two own clinical studies with orally administered EPL and PP in hyperlipoproteinaemic outpatients we were unable to establish clinically relevant effects on blood lipid and lipoprotein levels. In our opinion reported positive results with EPL, PP and cynarin are partially due to the methods of administration, selection of inpatients and dietary influences.