Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.

Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with a short cytoplasmic domain and an extracellular catalytic domain, controls a variety of physiological and pathological processes through the proteolytic degradation of extracellular or transmembrane proteins. MT1-MMP forms a complex on the cell membrane with its physiological protein inhibitor, tissue inhibitor of metalloproteinases-2 (TIMP-2). Here we show that, in addition to extracellular proteolysis, MT1-MMP and TIMP-2 control cell proliferation and migration through a non-proteolytic mechanism.

[Fascioliasis--a contribution to the differential diagnosis of focal liver processes].

The case of a 60 years old patient with a rare parasitosis, fascioliasis hepatica, is presented. The clinical, parasitologic, radiologic and histologic findings are discussed with reference to the literature. The diagnosis was established by examination of the faeces of the patient.

Tympanoplasty in children and anatomical variations of the epipharynx.

Short-term results or post-operative check-ups after tympanoplasties in children and adults are compared. There is no higher incidence of recurrent perforations in children. The distribution of air cells in adults and children does not vary, indicating that anatomic variations, rather than disease, are responsible for the sclerosis in the mastoid.

[Behavior of physical endurance and metabolism during acute beta 1 and beta 1/2-blockade].

Unlabelled: The effect of acute beta 1-blockade (100 mg metoprolol) and beta 1/2-blockade (2 mg levobunolol) on exercise performance and metabolism was studied in 16 healthy male physical education students. The study was carried out in a randomized double blind cross-over fashion. The maximal oxygen uptake was unchanged in all conditions, but maximal exercise capacity was reduced by 4% (beta 1-blockade) and 5% (beta 1/2-blockade).

[Relations between the nasopharynx, eustachian tube distance and maxillary shape].

The results of measurements of the impressions of palate and nasopharynx are compared. While choanes, anterior and medial nasopharynx grow in relation to age, the posterior width correlates with measurements of the maxilla, especially with the distance of molars and premolars. This means that in persons with wide maxillary dimensions, a wide nasopharynx can be expected.