Publications by authors named "W Savage"
Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of recurrent glioblastoma. This study addresses the need for non-invasive approaches to map heterogeneous landscape of histopathological alterations throughout the entire lesion for each patient. We developed BioNet, a biologically-informed neural network, to predict regional distributions of two primary tissue-specific gene modules: proliferating tumor (Pro) and reactive/inflammatory cells (Inf).
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- - Disruptive behavior disorders (DBDs), which include conduct disorder and oppositional defiant disorder, often overlap with ADHD, but there is a significant difference in their treatment and societal perceptions, pointing to a need for better diagnostic understanding.
- - Previous smaller studies have hinted at racial disparities in DBD diagnoses as compared to ADHD, prompting a larger investigation into these disparities using a comprehensive dataset of pediatric inpatients.
- - The study found that certain racial groups, including Native American, Asian, Black, and Hispanic children, were more likely to be diagnosed with DBDs when presenting symptoms similar to those of ADHD, highlighting important questions regarding race and mental health diagnoses.
Glioblastoma (GBM) is the most common primary brain cancer, comprising half of all malignant brain tumors. Patients with GBM have a poor prognosis, with a median survival of 14-15 months. Current therapies for GBM, including chemotherapy, radiotherapy, and surgical resection, remain inadequate.
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- Erythropoietic protoporphyria (EPP) causes painful sensitivity to light, impacting patients' quality of life, and researchers aimed to create a wearable device to measure light exposure.
- A pilot study involved five EPP patients using two different light dosimeters over three weeks to assess their light exposure levels.
- Findings indicated that increased exposure to blue light significantly raised the risk of symptoms, with the wristband device showing a predictive accuracy of 78%, suggesting it could effectively help manage EPP symptoms.
Intratumoral heterogeneity poses a significant challenge to the diagnosis and treatment of glioblastoma (GBM). This heterogeneity is further exacerbated during GBM recurrence, as treatment-induced reactive changes produce additional intratumoral heterogeneity that is ambiguous to differentiate on clinical imaging. There is an urgent need to develop non-invasive approaches to map the heterogeneous landscape of histopathological alterations throughout the entire lesion for each patient.
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