Publications by authors named "W Sakr"
Purpose: The Southwest Oncology Group (SWOG) coordinated an Intergroup study with the participation of Radiation Therapy Oncology Group (RTOG), and Eastern Cooperative Oncology Group (ECOG). This randomized phase III trial compared chemoradiotherapy versus radiotherapy alone in patients with nasopharyngeal cancers.
Materials And Methods: Radiotherapy was administered in both arms: 1.
The vulnerable primed cancer stem cells in disguise: demystifying the role of Maspin.
Cancer Metastasis Rev
December 2022
Article Synopsis
- Maspin is a special protein that helps stop tumors, but when found in certain cancer cells, it might actually mean a worse outcome for patients.
- Researchers suggest that cancer stem cells (CSCs) need to be 'primed' before they can grow into different types of cells, just like special stem cells in normal development.
- The study looks at how Maspin might help scientists understand these cancer stem cells better and create new treatments that target them, which could lead to better therapies for cancer.
Augmentation Mastopexy: A Five-step Standardized Strategy Approach.
Plast Reconstr Surg Glob Open
June 2022
Unlabelled: Planning a combined procedure requires ensuring an optimal fill of the reduced breast skin envelope, which in turn requires a system to quantify skin excess to ensure that the selected implant achieves that optimal fill. This has led us to develop a five-step approach that a surgical team can use to assess patients scheduled to undergo an augmentation mastopexy and arrive at an optimal surgical strategy.
Methods: This retrospective study included 50 consecutive cases where layered mastopexies combined with augmentation mammaplasties were performed.
Article Synopsis
- Scientists studied small kidney tumors called "papillary renal neoplasms with reverse polarity" (PRNRP) that are often found by accident.
- They looked at 50 of these tumors from 46 patients and found that the smaller tumors were usually under 5 mm, while the larger ones were over 5 mm.
- They discovered that many of the tumors had mutations in a gene called KRAS, especially the larger ones, suggesting that these mutations might happen early in the tumors' development.
The autophagy-lysosome pathway and apoptosis constitute vital determinants of cell fate and engage in a complex interplay in both physiological and pathological conditions. Central to this interplay is the archetypal autophagic cargo adaptor p62/SQSTM1/Sequestosome-1 which mediates both cell survival and endoplasmic reticulum stress-induced apoptosis via aggregation of ubiquitinated caspase-8. Here, we investigated the role of p62-mediated apoptosis in head and neck squamous cell carcinoma (HNSCC), which can be divided into two groups based on human papillomavirus (HPV) infection status.
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