Publications by authors named "W Sakhor"
Article Synopsis
- - The study focuses on understanding how HIV-1 latency is established and maintained, which is crucial for targeting the virus effectively.
- - Researchers introduced a new model called HIV-Timer of cell kinetics and activity (HIV-Tocky) that uses dual fluorescence to track HIV provirus silencing and reactivation, allowing for a better analysis of latent HIV populations.
- - The HIV-Tocky model distinguishes between two types of latent cells: those that are directly latent and those that have recently silenced, thereby enhancing our understanding of HIV reservoirs and potential treatment strategies to eliminate the virus.
The hepatitis C virus (HCV) consists of eight genotypes and 90 subtypes, with genotype (GT) 3 being the second most common globally and is linked to higher incidences of steatosis and rapid development of fibrosis and cirrhosis. The NS3/4A serine protease, a heterodimer complex of two HCV non-structural proteins, is an effective target for pharmaceutical intervention due to its essential roles in processing HCV polyproteins and inhibiting innate immunity. This study combines structure-based virtual screening (SBVS) of predefined compound libraries, pharmacokinetic prediction (ADME/T) and in vitro evaluation to identify potential low molecular weight (<500 Dalton) inhibitors of the NS3/4A serine protease (GT3).
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