Design, Synthesis, In Vitro, and In Silico Studies of New -Substituted-pyrazolo[3,4-]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors.

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide.

Retinal changes and cardiac biomarker assessment in relation to chronic kidney disease: a single centre study.

Background: The prevalence of chronic kidney disease (CKD) is rising in Malaysia. Early detection is necessary to prevent disease progression, especially in terms of cardiovascular (CV) risk, the main cause of death in end-stage renal disease (ESRD). Retinal changes have proven to be a good predictor of CKD whereas cardiac biomarkers are useful in cardiovascular risk stratification.

A rarely described Kimura's disease of the breast.

Kimura's disease is a rare chronic inflammatory disease of unknown aetiology. The majority of cases are reported in middle-aged Asian males and rarely seen in other ethnicities. Patients classically present with chronic single or multiple painless subcutaneous masses, lymphadenopathies, hypereosinophilia and elevated serum immunoglobulin E.

Performance Analysis of a Novel Hybrid Segmentation Method for Polycystic Ovarian Syndrome Monitoring.

Experts have used ultrasound imaging to manually determine follicle count and perform measurements, especially in cases of polycystic ovary syndrome (PCOS). However, due to the laborious and error-prone process of manual diagnosis, researchers have explored and developed medical image processing techniques to help with diagnosing and monitoring PCOS. This study proposes a combination of Otsu's thresholding with the Chan-Vese method to segment and identify follicles in the ovary with reference to ultrasound images marked by a medical practitioner.

Imperfections Formation in Thin Layers of NiTi Triply Periodic Minimal Surface Lattices Fabricated Using Laser Powder Bed Fusion.

In this paper, thin layers of NiTi shape memory alloy (SMA) triply periodic minimal surface lattices (TPMS) are fabricated using laser powder bed fusion (LPBF), considering different laser scanning strategies and relative densities. The obtained architected samples are studied using experimental methods to characterize their microstructural features, including the formation of cracks and balling imperfections. It is observed that balling is not only affected by the parameters of the fabrication process but also by structural characteristics, including the effective densities of the fabricated samples.