Publications by authors named "W S Zai"
Article Synopsis
- Current anti-HBV therapies have limitations, leading researchers to explore HBV core protein assembly modulators (CpAMs) as potential new treatments.
- The study developed a high-throughput screening system to identify novel CpAMs from a marine chemicals library, discovering a promising compound derived from naamidine J with effective anti-HBV activity.
- This compound not only inhibited HBV replication in cell models but also showed a synergistic effect with existing treatments and proved to be safe in mouse models, indicating its potential for future anti-HBV therapies.
Unlabelled: The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA minichromosome. Utilizing both cell and mouse cccDNA models, we compared the inhibitory effects of IFNα, siRNA, and their combination on cccDNA activity and assessed its epigenetic state.
View Article and Find Full Text PDFHypertensive heart disease was difficult to cure with drugs, and most patients had poor compliance, leading to recurrent disease and poor quality of life. The intelligent management mode based on the Internet of Things avoided the excessive dependence of the elderly patients on medical institutions in the traditional medical model and enabled patients to monitor themselves. This study aimed to explore the impact on self-management ability and prognosis of elderly patients with hypertensive heart disease.
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- Researchers developed a dual-targeting peptide, DBCO-pYCCK6, that quickly attaches to cancer cell membranes and enhances the delivery of type-I photosensitizers (PSs) for cancer treatment.
- * This method improves the labeling speed and targeting of PSs, leading to the effective generation of reactive oxygen species (ROS) upon light exposure, which induces a specific form of cell death called pyroptosis.
- * In vivo tests showed that this peptide and PS combination significantly reduced tumor growth while promoting immune responses from CD8 cytotoxic T cells, demonstrating a new approach for cancer therapy.
The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) is organized as a minichromosome structure in the nucleus of infected hepatocytes and considered the major obstacle to the discovery of a cure for HBV. Until now, no strategies directly targeting cccDNA have been advanced to clinical stages as much is unknown about the accessibility and activity regulation of the cccDNA minichromosome. We have described the method for evaluation of the cccDNA minichromosome accessibility using micrococcal nuclease-quantitative polymerase chain reaction and high-throughput sequencing, which could be useful tools for cccDNA research and HBV cure studies.
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