Publications by authors named "W S Tae"
Investigating the changes in volumes of the limbic system and hypothalamic-subnuclei in patients with depression.
Psychiatry Res Neuroimaging
December 2024
Background: Depression is consistently linked to changes in the hypothalamus, HPA axis, and limbic system, though the specific substructures involved remain unclear. This study aims to explore the relationship between depression and the volumes of specific nuclei within these brain regions. Understanding these connections could provide deeper insights into the biological mechanisms underlying depression.
View Article and Find Full Text PDFBackground And Purpose: Tinnitus is a condition in which individuals perceive sounds, such as ringing or buzzing, without any external source. Although the exact cause is not fully understood, recent studies have indicated the involvement of nonauditory brain structures, including the limbic system. We aimed to compare the volumes of specific brain structures between patients with tinnitus and controls.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the connection between inflammation and brain function in major depressive disorder (MDD), noting that patients with MDD have higher levels of proinflammatory cytokines like IL-6 and IL-8 compared to healthy controls.
- - Researchers analyzed resting-state functional connectivity (RSFC) in 76 MDD patients and 92 healthy individuals, finding significant changes in brain regions related to emotion and cognitive control networks.
- - The results indicate that higher levels of the inflammatory marker TNF-α are positively linked to changes in RSFC in specific brain areas in MDD patients, pointing to a potential role of inflammation in disrupting brain functions related to mood and cognition.
Background: Epigenetic modifications, such as DNA methylation, contribute to the pathophysiology of major depressive disorder (MDD). This study aimed to identify novel MDD-associated epigenetic loci using DNA methylation profiles and explore the correlations between epigenetic loci and cortical thickness changes in patients with MDD.
Methods: A total of 350 patients with MDD and 161 healthy controls (HCs) were included in the epigenome-wide association studies (EWAS).