Publications by authors named "W S Lexmond"

Background: Understanding pain and its mechanisms can play an important role in (post-) cancer rehabilitation. In order to test patient's knowledge of pain, the Revised Neurophysiology of Pain Questionnaire was developed and translated into Dutch (RNPQ-NL). However, its psychometric properties have not been examined yet.

View Article and Find Full Text PDF

Inflammatory bowel diseases (IBDs) are chronic, immune-mediated disorders that include Crohn's disease and ulcerative colitis. A pediatric onset of disease occurs in about 10% of all cases. Clinical presentation of IBD with rectal bleeding or perianal disease warrants direct referral for endoscopic evaluation.

View Article and Find Full Text PDF

There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered.

View Article and Find Full Text PDF
Article Synopsis
  • Long-term use of anti-TNF-α agents can lead to infections and skin reactions, and this study reviews whether reducing the dose or extending intervals can lessen these effects.
  • A systematic review included 14 randomized controlled trials and 6 observational studies with a total of 2706 patients suffering from conditions like rheumatoid arthritis and psoriasis.
  • Results indicate that de-escalation strategies did not significantly lower the rates of infections or skin manifestations compared to standard dosing, and inconsistencies in reporting limited deeper analysis.
View Article and Find Full Text PDF