Publications by authors named "W S Etches"
Background: The interaction of blood with foreign artificial surfaces during cardiopulmonary bypass (CPB) has been recognized as a major stimulus in evoking a systemic inflammatory and metabolic response. Phosphorylcholine (PC) is a new-generation coating material designed to ameliorate biocompatibility and thereby to reduce the detrimental interactions of CPB. We studied the effects of PC-coated perfusion circuits on platelet function and the humoral and cellular response to CPB.
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- Hemostatic disturbances often occur in newborns who experience asphyxia, particularly after resuscitation efforts.
- The study involved hypoxic newborn piglets that were reoxygenated with different oxygen concentrations (21% vs. 100%) and examined for changes in platelet function and plasma markers post-resuscitation.
- Findings indicated that reoxygenation led to impaired platelet aggregation and increased plasma activity of MMP-9, with high oxygen levels exacerbating platelet activation and potentially elevating TxB2 levels.
Objectives: The purpose of this study was to determine the biological stability of heparin and to test for physical compatibility in heparin/antibiotic solutions in concentrations suitable for antibiotic lock therapy.
Methods: Solutions were prepared with heparin 5000 U/mL or heparin 10 U/mL and cefazolin 10 mg/mL, ampicillin 10 mg/mL, or piperacillin 40 mg/mL. Solutions of vancomycin 2.