An economic analysis of preimplantation genetic testing for aneuploidy by polar body biopsy in advanced maternal age.

Objective: What are the cost per live birth and the incremental cost of preventing a miscarriage with preimplantation genetic testing for aneuploidy (PGT-A) by polar body biopsy and array-based comprehensive genome hybridisation (aCGH) versus regular IVF/ICSI without PGT-A for infertility treatment in women 36-40 years of age?

Design: Decision tree model.

Population: A randomised clinical trial on PGT-A (ESTEEM study).

Methods: Two treatment strategies were compared: one cycle of IVF/ICSI with or without PGT-A.

Genetic Testing for Autism Spectrum Disorder is Lacking Evidence of Cost-effectiveness. A Systematic Review.

Background: Autism Spectrum Disorder (ASD) is a highly heritable neural development disorder characterized by social impairment. The earlier the diagnosis is made, the higher are the chances of obtaining relief of symptoms. A very early diagnosis uses molecular genetic tests, which are also offered commercially.