A 3D bioreactor model to study osteocyte differentiation and mechanobiology under perfusion and compressive mechanical loading.

Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in bone. As a result, they secrete signaling molecules that mediate bone formation and resorption. To date, few three-dimensional (3D) models exist to study the response of mature osteocytes to biophysical stimuli that mimic fluid shear stress and substrate strain in a mineralized, biomimetic bone-like environment.

Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics.

Unlabelled: Multiple myeloma involves early dissemination of malignant plasma cells across the bone marrow; however, the initial steps of dissemination remain unclear. Human bone marrow-derived mesenchymal stromal cells (hMSC) stimulate myeloma cell expansion (e.g.

Disposition and clinical side effects of pentazocine when administered during day and night.

The question of possible circadian rhythm upon administration of 6,11-dimethyl-2,6-methano-3-(3-methyl-2-butenyl)-1,2,3,4,5,6-hexahydro-3- benzazocin-8-ol (pentazocine, Talwin) (which was found to exist in beagle dogs) was studied in eight healthy, male volunteers. Six of the subjects resided in the USA, and two subjects joined the study group the night before the morning experiment from Europe. All blood concentration-time data after i.

[Treatment of menstrual cycle associated migraine].

A high percentage of migraine in women is closely related to the menstrual cycle either at the time of ovulation or in the perimenstrual period. It can be assumed that rapid serum fluctuations due to the decline of serum estrogens and or progesterone trigger this type of headache. With respect to a possible endocrine mechanism a hormonal treatment seems to be useful in order to avoid migraine or at least to decrease the complaints.