Publications by authors named "W Rich"

Introduction: Accommodation is the process of changing the ocular lens' refractive power and focal distance. This process involves application of biomechanical forces on the lens by the surrounding musculature. Previous studies have demonstrated that the lens epithelium demonstrates mechanotransduction and that tension influences its chemical activity.

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Article Synopsis
  • RNA sequencing (RNA-seq) is being used to enhance diagnostics in cases where DNA testing doesn't provide clear answers, particularly for detecting abnormal gene expression and splicing patterns.
  • The study analyzed blood samples from 86 patients with suspected genetic disorders, focusing on identifying splicing abnormalities and gene expression outliers in VUSs and undiagnosed cases.
  • The results showed that RNA-seq helped diagnose four new cases by revealing novel splicing events and provided insights into the utility of RNA analysis for improving diagnostic outcomes in genetic disorders.
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The ability to identify individual animals can provide valuable insights into the behaviour, life history, survivorship, and demographics of wild populations. Photo-identification (photo-ID) uses unique natural markings to identify individuals and can be effective for scalable and non-invasive research on marine fauna. The successful application of photo-ID requires that chosen distinguishing markings are unique to individuals and persist over time.

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Importance: Compared with early cord clamping (ECC), umbilical cord milking (UCM) reduces delivery room cardiorespiratory support, hypoxic-ischemic encephalopathy, and therapeutic hypothermia in nonvigorous near-term and full-term infants. However, UCM postdischarge outcomes are not known.

Objective: To determine the 2-year outcomes of children randomized to UCM or ECC at birth in the Milking in Nonvigorous Infants (MINVI) trial.

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The biomechanical properties of the ocular lens are essential to its function as a variable power optical element. These properties change dramatically with age in the human lens, resulting in a loss of near vision called presbyopia. However, the mechanisms of these changes remain unknown.

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