Premature calcifications of costal cartilages: a new perspective.

Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete.

Long-term survival in patients with incurable breast cancer. An analysis of 93 cases.

Background/aim: The aim of this study was to elucidate why some patients with incurable breast cancer may survive far beyond our expectation.

Patients And Methods: The analysis is based on two cohorts of patients with unresectable locoregional recurrences or distant metastases. Survival time, tumor characteristics, disease-free interval, metastasis type, coexistent diseases and a family history for breast cancer were recorded.

Treatment of vascular soft tissue sarcomas with razoxane, vindesine, and radiation.

Purpose: In previous studies, razoxane and vindesine together with radiotherapy was proved to be effective in soft tissue sarcomas (STS). Because razoxane leads to a redifferentiation of pathological tumor blood vessels, it was of particular interest to study the influence of this drug combination in vascular soft tissue sarcomas.

Methods And Materials: This open multicenter Phase II study was performed by the Austrian Society of Radiooncology.

Razoxane and vindesine in advanced soft tissue sarcomas: impact on metastasis, survival and radiation response.

Background: The treatment options in advanced soft tissue sarcomas (STS) are limited. In a pilot study, an antimetastatic and radiosensitizing treatment concept was explored.

Patients And Methods: Twenty-one patients with unresectable and/or oligometastatic STS received the drugs razoxane and vindesine supported by radiotherapy and surgery.

Combined vindesine and razoxane shows antimetastatic activity in advanced soft tissue sarcomas.

Background: Razoxane and vindesine were shown to suppress distant metastasis in animal systems. Both drugs affect main steps of the metastatic cascade. Therefore, a pilot study was performed to study the influence of these drugs on the dynamics of metastasis in advanced soft tissue sarcomas (STS).