Publications by authors named "W Reik"
Article Synopsis
- - The study investigates early human trophoblast development using marmoset embryos, bridging gaps in understanding due to the inaccessibility of human early conceptus.
- - Researchers successfully created trophoblast stem cells (TSCs) from marmoset pluripotent stem cells, demonstrating unique characteristics and differentiation potential compared to human TSCs.
- - The findings suggest that specific culture conditions for marmosets can maintain a trophoblast-like identity, revealing insights into evolutionary differences in implantation and enhancing knowledge of human development.
Ageing is the accumulation of changes and decline of function of organisms over time. The concept and biomarkers of biological age have been established, notably DNA methylation-based clocks. The emergence of single-cell DNA methylation profiling methods opens the possibility of studying the biological age of individual cells.
View Article and Find Full Text PDFArticle Synopsis
- Mammalian embryos form blastocysts with a trophectoderm (TE) layer and an inner cell mass (ICM), which are essential for implantation, differing by species.
- Murine embryos have a single-layered TE until they implant, while human blastocysts attach directly to the uterine wall with a unique TE structure.
- Research shows human TE may multi-layer before implantation, crucial for securing the embryo and starting placenta formation, with most inner TE cells originating from the outer TE rather than the ICM.
Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required during germ cell development and meiosis. One pathway implicated in human fertility is DNA translesion synthesis (TLS), which allows replication impediments to be bypassed.
View Article and Find Full Text PDFHuman pluripotent stem cells (hPSCs) are of fundamental relevance in regenerative medicine. Naïve hPSCs hold promise to overcome some of the limitations of conventional (primed) hPSCs, including recurrent epigenetic anomalies. Naïve-to-primed transition (capacitation) follows transcriptional dynamics of human embryonic epiblast and is necessary for somatic differentiation from naïve hPSCs.
View Article and Find Full Text PDF