Publications by authors named "W Reid"
In our ears, outer-hair-cell bundles (OHBs) convert sound-induced forces into receptor currents that drive cochlear amplification, the process responsible for the micropascal-scale threshold and million-fold dynamic range of hearing. OHBs rely on gating springs to open mechanoelectrical-transduction (MET) ion channels, through which the receptor current flows. OHBs have larger gating-spring stiffnesses than other types of hair bundles, but we have a poor understanding of how gating-spring stiffness contributes to OHB mechanics and receptor-current regulation.
View Article and Find Full Text PDFThe establishment of a productive dengue virus (DENV) infection in the midgut epithelial cells of is critical for the viral transmission cycle. The hypothesis that DENV virions interact directly with specific mosquito midgut proteins was explored. We found that DENV serotype 2 (DENV2) pretreated with trypsin interacted with a single 31 kDa protein, identified as AAEL011180 by protein mass spectrometry.
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- - The study investigates how inspiratory threshold loading (ITL) affects cognition and prefrontal cortex (PFC) activity compared to lower limb pedalling during dual tasks, finding that ITL leads to more cognitive impairment and increased PFC activity.
- - Thirty healthy participants performed various tasks, including ITL and pedalling, while their cognitive performance and PFC activity were measured using functional near-infrared spectroscopy.
- - Results showed that ITL-Stroop significantly impaired reaction time and accuracy more than pedalling-Stroop, and ITL caused higher feelings of dyspnoea and exertion, indicating ITL creates more cognitive interference than rhythmic pedalling.
Article Synopsis
- - The study investigated the occurrence of post-insufflation diaphragm contractions (PIDCs) during mechanical ventilation, particularly focusing on whether these contractions are linked to different ventilation modes and patient characteristics in patients with hypoxemic respiratory failure.
- - Data were collected from 47 patients over several days, analyzing diaphragm electromyography and ventilatory parameters to categorize breaths and identify instances of PIDC under various conditions, including reverse-triggering and other ventilatory modes.
- - Results indicated that PIDCs were most common during reverse-triggering (74%) compared to other modes, and were linked to factors such as diaphragm activity, ventilatory timing, and patient-specific parameters, highlighting the complexities of ventilator settings on diaphragm function.