Publications by authors named "W R Veldkamp"
Article Synopsis
- A balanced immune system is crucial for defending against infections and preventing autoimmune diseases; an ineffective response allows infections to thrive, while uncontrolled activation can cause inflammatory disorders.
- Researchers screened 1200 small molecules to find drugs that can modify immune cell functions, focusing on T cells, B cells, and polymorphonuclear leukocytes (PMNs) for chronic inflammatory diseases.
- They identified candidate drugs like pyrvinium pamoate, which effectively suppressed B cell activation and slowed down an autoimmune condition, and studied mechanisms in gene-deleted mice to further understand how these actions occur, paving the way for potential drug repurposing to manage immune responses.
Article Synopsis
- The study investigates the impact of psoriasis on patients' work and daily life activities as they start using biological treatments.
- Data from 194 patients showed that after beginning treatment, disease activity significantly decreased, yet work participation remained lower than the general population.
- Although employed patients exhibited improved productivity, nearly half still faced challenges in daily activities, with no significant changes observed over time.
Purpose: In digital breast tomosynthesis (DBT), radiologists need to review a stack of 20 to 80 tomosynthesis images, depending upon breast size. This causes a significant increase in reading time. However, it is currently unknown whether there is a perceptual benefit to viewing a mass in the 3D tomosynthesis volume.
View Article and Find Full Text PDFImportance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.
Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.