Publications by authors named "W R Stenzel"
Article Synopsis
- Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathies, characterized by symptoms like muscle inflammation, lung issues, arthritis, rashes, and fever.
- Muscle biopsies reveal unique morphological features that help differentiate Antisynthetase syndrome from other myositis types.
- The workshop aims to establish a consensus on the syndrome's definition, discuss clinical and laboratory profiles, and provide management strategies and classification criteria.
Objectives: To investigate the histopathological features of the temporalis muscle (TM) and adjacent nerve tissue in active cranial giant cell arteritis (C-GCA).
Methods: Temporal artery biopsy (TAB) specimens containing fragments of the TM from patients with active C-GCA fulfilling the 2022 ACR/EULAR classification criteria (n = 11) were assessed by conventional histology and immunohistochemistry in comparison with non-GCA controls (n = 3). Clinical, laboratory and imaging features based on patient charts at time of biopsy were retrospectively recorded.
Article Synopsis
- The peripheral nervous system and skeletal muscle are commonly affected in systemic vasculitis, leading to symptoms like myalgia, muscle weakness, and sensory deficits.
- Vasculitic myopathy (VM) is marked by severe muscle pain but normal creatine kinase levels, and can be identified by MRI, while vasculitic neuropathy (VN) causes motor and sensory deficits, especially in the lower limbs.
- Diagnosing these conditions typically involves histopathological examination of nerve and muscle biopsies, which is crucial for determining treatment strategies.