Publications by authors named "W R Kates"
Background: 22q11.2 deletion syndrome (22qDel) is a copy number variant that is associated with psychosis and other neurodevelopmental disorders. Adolescents who are at clinical high risk for psychosis (CHR) are identified based on the presence of subthreshold psychosis symptoms.
View Article and Find Full Text PDFMental health, coping, and protective factors in mothers of children with 22q11.2 deletion syndrome.
Am J Med Genet B Neuropsychiatr Genet
September 2024
Compared to the large body of maternal mental health research for other pediatric disorders, we know far less about the experience of mothers of children with 22q11DS. This study investigates the coping methods, protective factors, and mental health of this population. These findings might lead to better support for 22q11DS maternal mental health.
View Article and Find Full Text PDFArticle Synopsis
- 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion in humans, linked to reduced gray matter volume and neuropsychiatric issues like cognitive impairment and psychosis.
- A study involving 783 participants (470 with 22q11DS and 313 controls) used advanced brain imaging techniques to identify specific patterns of gray matter volume covariance associated with this syndrome.
- Results indicated that individuals with 22q11DS show unique structural brain abnormalities, particularly in the cerebellum, and these alterations follow distinct patterns rather than a widespread decline.
Congenital heart disease (CHD) affecting the conotruncal region of the heart, occurs in 40-50% of patients with 22q11.2 deletion syndrome (22q11.2DS).
View Article and Find Full Text PDFBackground: Sensory processing differences are reported both in children with ADHD and in children with autism. Given the substantial overlap between autism and ADHD, the current study examined which sensory features were uniquely predictive of autistic traits after controlling for ADHD symptoms, age, IQ, and sex in a sample of children and adolescents with autism aged 6-17 years.
Methods: The sample included 61 children and adolescents with autism.