Publications by authors named "W R Heinz"
Much of the human genome is transcribed into RNAs, many of which contain structural elements that are important for their function. Such RNA molecules-including those that are structured and well-folded-are conformationally heterogeneous and flexible, which is a prerequisite for function, but this limits the applicability of methods such as NMR, crystallography and cryo-electron microscopy for structure elucidation. Moreover, owing to the lack of a large RNA structure database, and no clear correlation between sequence and structure, approaches such as AlphaFold for protein structure prediction do not apply to RNA.
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- The study focuses on specific clusters of CD8+ T cells, categorized as CD8-NOS2+COX2+ and CD8-NOS2-COX2+, which play a significant role in the immune response to tumors.
- These unique cellular environments affect the spatial structure of CD8+ T cell interactions within tumors and can influence patient outcomes.
- The findings suggest that existing treatments, like NOS inhibitors and NSAIDs, could potentially target these cellular neighborhoods to improve cancer therapy.
Purpose: Surrogate end points are commonly used to estimate treatment efficacy in clinical studies of chronic lymphocytic leukemia (CLL). This patient- and trial-level analysis describes the correlation between progression-free survival (PFS) and minimal residual disease (MRD) with overall survival (OS) in first-line trials for CLL.
Patients And Methods: First, patient-level correlation was confirmed using source data from 12 frontline German CLL Study Group (GCLLSG)-trials.
Background: Point-of-care ultrasound (POCUS) is steadily growing in use in prehospital emergency medicine. While currently used primarily by emergency physicians, POCUS could also be employed by paramedics to support diagnosis and decision-making. Yet to date, no paramedicine-targeted POCUS curricula exist in Germany.
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- Immune therapy is becoming a key approach in cancer treatment, particularly for aggressive types like triple negative breast cancer (TNBC), where factors like COX2 limit treatment effectiveness.
- A study revealed that combining radiation with the anti-inflammatory drug indomethacin significantly boosted the immune response, reduced tumor growth, and lowered metastasis in mouse models of TNBC.
- The combination treatment led to better local control of tumors and increased survival rates by enhancing immune activity, suggesting that existing NSAIDs could improve the success of radiation therapy in cancer patients.