Real-time organ perfusion monitoring of human kidney transplants using normothermic perfusion and reflectance spectroscopy.

Transplantation is the standard treatment for end-stage kidney disease but carries with it a non-trivial risk of post-operative complication. There is a need for a continuous, real-time, not additionally invasive method of monitoring organ perfusion. We present an approach to allograft perfusion monitoring using a human kidney model using normothermic perfusion (EVNP) and custom spectroscopic optical reflectance probes.

Payers' perspectives on wound care coverage policy determination: what we know and ways to move forward.

Many coverage challenges in wound care stem from a lack of shared clarity among researchers, manufacturers, payers, and regulators about the clinical evidence payers need to make positive coverage determinations. The Alliance of Wound Care Stakeholders, a multidisciplinary trade association, convened its Wound Care Evidence Summit in May 2022 to explore this issue and identify shared challenges and solutions with a diverse range of policymakers, payers, and researchers. This article focuses on payers' clinical evidence requirements and the processes used when making coverage determinations, as discussed at the Summit.

Nedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8).

Background: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and renal failure, with potentially life-threatening systemic oxalosis. Nedosiran is a synthetic RNA interference therapy, designed to reduce hepatic lactate dehydrogenase (LDH) to decrease oxalate burden in PH.

Physiological responses to aversive and non-aversive audiovisual, auditory, and visual stimuli.

We examined differences in physiological responses to aversive and non-aversive naturalistic audiovisual stimuli and their auditory and visual components within the same experiment. We recorded five physiological measures that have been shown to be sensitive to affect: electrocardiogram, electromyography (EMG) for zygomaticus major and corrugator supercilii muscles, electrodermal activity (EDA), and skin temperature. Valence and arousal ratings confirmed that aversive stimuli were more negative in valence and higher in arousal than non-aversive stimuli.

Thermally and Base-Triggered "Debond-on-Demand" Chain-Extended Polyurethane Adhesives.

A series of novel chain-extended polyurethanes (CEPUs) featuring degradable sulfonyl ethyl urethane chain-extenders that permit degradation under base-triggered conditions to afford "debond-on-demand" elastomeric adhesives are reported. Exposure of the CEPUs to -butylammonium fluoride (TBAF) triggered the degradation of the sulfonyl ethyl urethane chain-extenders. Lap shear adhesion tests of the CEPUs exposed to TBAF revealed reductions in shear strength of up to 65% for both aluminum and glass substrates, from 2.