Publications by authors named "W R Haas"
Using participatory, virologic, and wastewater surveillance systems, we estimated when and to what extent reported data of adult COVID-19 cases underestimated COVID-19 incidence in Germany. We also examined how case underestimation evolved over time. Our findings highlight how community-based surveillance systems can complement official notification systems for respiratory disease dynamics.
View Article and Find Full Text PDFBiliary tract cancers (BTCs) are a group of deadly malignancies encompassing intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. Here, we present the integrative analysis of 63 BTC cell lines via multi-omics clustering and genome- scale CRISPR screens, providing a platform to illuminate BTC biology and inform therapeutic development. We identify dependencies broadly enriched in BTC compared to other cancers as well as dependencies selective to the anatomic subtypes.
View Article and Find Full Text PDFArticle Synopsis
- The gene IDH1 often changes in many cancers, leading to a harmful substance that messes with the body's natural defenses.
- Tumors with this change often keep immune cells out, but blocking the mutant IDH1 can help the body's immune system attack the cancer.
- The study shows that the mutant IDH1 silences certain genes that would usually help the immune system work, but stopping this mutation can help reactivate those genes and boost immunity against tumors.
Article Synopsis
- * In fission yeast, small RNAs previously thought to be essential are not necessary for the nucleation of the H3K9 methyltransferase Clr4/SUV39H at heterochromatic regions; instead, the Mtl1 and Red1 core complex can initiate this process at long noncoding RNAs.
- * The study shows that the interaction of Clr4 with H3K9 deacetylases leads to a cycle of deacet