New Synthetic Lethality Re-Sensitizing Platinum-Refractory Cancer Cells to Cisplatin In Vitro: The Rationale to Co-Use PARP and ATM Inhibitors.

The pro-apoptotic tumor suppressor BIN1 inhibits the activities of the neoplastic transcription factor MYC, poly (ADP-ribose) polymerase-1 (PARP1), and ATM Ser/Thr kinase (ATM) by separate mechanisms. Although BIN1 deficits increase cancer-cell resistance to DNA-damaging chemotherapeutics, such as cisplatin, it is not fully understood when BIN1 deficiency occurs and how it provokes cisplatin resistance. Here, we report that the coordinated actions of MYC, PARP1, and ATM assist cancer cells in acquiring cisplatin resistance by deficits.

Evaluation of a Process by which Individual Interest Supports Learning within a Formal Middle School Classroom Context.

The affective domain and its impact on science achievement has been studied with increasing attention over the past decade. However, there has been little empirical work on how individual interest, and facilitation of situational interest in the classroom, facilitates learning of concepts within fine-grained units of instruction. Drawing upon previous theoretical and empirical work, we test the hypothesis that individual interest facilitates situational interest, and that this in turn facilitates content learning, with respect to a 10-day health education intervention focused on teaching middle school students about light, color and vision.

Changes in the Harpagide, Harpagoside, and Verbascoside Content of Field Grown and in Response to Season and Shade.

Pursh and L. are two common species within the Scrophulariaceae family that are endemic to North America. Historically, these species were used by indigenous peoples and colonialists to treat sunburn, sunstroke, frostbite, edema, as well as for blood purification, and in women's health.