Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial.

Background: SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. This phase II study aimed to verify the efficacy and safety of SHEN26 in COVID-19 patients.

Effects of Evaporation and Body Thermal Plume on Cough Droplet Dispersion and Exposure Risk for Queuing People.

The transmission of virus-containing droplets among multiple people in an outdoor environment is seldom evaluated. In this study, an Euler-Lagrange computational fluid dynamics approach was used to investigate the effects of evaporation and the body thermal plume on the dispersion of coughed droplets under various wind conditions, and the infection risk was evaluated for various arrangements of individuals queuing outdoors using virtual manikin models. The evaporation time was longer for larger droplets and in a more humid environment.

eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53.

Eukaryotic translation initiation factor 4A1 (eIF4A1) is an ATP-dependent RNA helicase that participates in a variety of biological and pathological processes such as cell proliferation and apoptosis, and cancer. In this study we investigated the role of eIF4A1 in ischemic heart disease. The myocardial ischemia/reperfusion (I/R) model was established in mice by ligation of the left anterior descending artery for 45 min with the subsequent reperfusion for 24 h; cultured neonatal mouse ventricular cardiomyocytes (NMVCs) treated with HO (200 μM) or H/R (12 h hypoxia and 12 h reoxygenation) were used for in vitro study.

One-Pot Synthesis and Enhanced Vis-NIR Photocatalytic Activity of NiTiO/TiO Templated by Waste Tobacco Stem-Silks.

Synthesis of the photocatalysts with near-infrared light response usually involves upconversion materials or plasmon-assisted noble metals. Herein, NiTiO/TiO was synthesized by using waste tobacco stem-silks as biotemplates and tetra-tert-butyl orthotitanate and nickel nitrate as precursors in a one-pot procedure. NiTiO(1.

Access to Chiral Bridged Biaryls via Brønsted Acid-Catalyzed Asymmetric Addition of Alcohols to Fluoroalkylated Biaryl Oxazepines.

We disclose herein a chiral phosphoric-acid-catalyzed enantioselective addition reaction of alcohols to fluoroalkylated biaryl 1,3-oxoazepines, which furnished a wide range of bridged biaryls bearing a fluoroalkylated quaternary carbon stereocenter on the seven-membered ring in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). Our method can be used for the modification of several natural products and bioactive molecules. Preliminary studies revealed that the products obtained in this reaction exhibit good in vitro bioactivities against two plant pathogens.