Transvaginal natural orifice specimen extraction surgery for left-sided colorectal resection: A single-centre cohort study.

Introduction: Transvaginal natural orifice specimen extraction surgery (NOSES) is an innovative and feasible approach for left-sided colorectal resections in females. This study aimed to report our experience with transvaginal NOSES for left-sided laparoscopic colorectal resections.

Patients And Methods: We analysed data for all patients with transvaginal extraction performed for left-sided laparoscopic colorectal resections between 2011 and 2021 at a tertiary teaching hospital in Taiwan.

The Softening of Persimmon Fruit Was Inhibited by Gibberellin via DkDELLA1/2.

Texture is an important quality index reflecting a series of sensory evaluations of fruit, and softening is the main texture change of most postharvest fruit. Persimmon fruit () shows a pattern of decreasing firmness after harvest, leading to a short duration of sale and excessive waste. We found that the treatment with gibberellin (GA) could effectively inhibit the postharvest softening of persimmon fruit, but the underlying mechanism is unclear.

Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.

KRAS is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the clinical management of patients with G12C mutation and advanced our understanding of its function. However, little is known about the targeted disruption of KRASG12V, partly due to a lack of specific inhibitors.

An attention-based motor imagery brain-computer interface system for lower limb exoskeletons.

Lower-limb exoskeletons have become increasingly popular in rehabilitation to help patients with disabilities regain mobility and independence. Brain-computer interface (BCI) offers a natural control method for these exoskeletons, allowing users to operate them through their electroencephalogram (EEG) signals. However, the limited EEG decoding performance of the BCI system restricts its application for lower limb exoskeletons.

Predictive Scores for Identifying Chronic Opioid Dependence After General Anesthesia Surgery.

Purpose: To address the prevalence and risk factors of postoperative chronic opioid dependence, focusing on the development of a predictive scoring system to identify high-risk populations.

Methods: We analyzed data from the Taiwan Health Insurance Research Database spanning January 2016 to December 2018, encompassing adults undergoing major elective surgeries with general anesthesia. Patient demographics, surgical details, comorbidities, and preoperative medication use were scrutinized.