Publications by authors named "W Pommer"
Article Synopsis
- - Falls are a major public health issue, especially among older adults (≥60 years) in care settings, leading to serious physical and psychological problems; hence, accurate fall risk assessments are vital for prevention and individualized care.
- - This study evaluated the Fall Risk Score (FRS) using real-world data from 617 elderly individuals in Germany to determine its effectiveness in predicting falls over time and to identify critical threshold values.
- - Results indicated a strong correlation between higher FRS scores and an increased number of falls, particularly in participants with slower gait speeds and those using walking aids, emphasizing the FRS's prognostic validity for fall risk assessment.
The quality of general obesity management before bariatric surgery (BS) is rarely investigated. Inadequate information regarding undetected and undiagnosed comorbidities (UUCs) in individuals with obesity may influence the penetration, risks, and outcomes of BS. We conducted a cohort study involving a pre-specified medical check-up in a cooperation between a BS department and an outpatient medical centre.
View Article and Find Full Text PDFBackground: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist Ang-2 can promote endothelium permeability and vascular destabilization, hence contributing to a poor outcome in vascular diseases via endothelial injury, vascular dysfunction, and microinflammation.
View Article and Find Full Text PDFChronic kidney disease (CKD) often culminates in hypercalcemia, instigating severe neurological injuries that are not yet fully understood. This study unveils a mechanism, where GSK343 ameliorates CKD-induced neural damage in mice by modulating macrophage polarization through the EZH2/MST1/YAP1 signaling axis. Specifically, GSK343 downregulated the expression of histone methyltransferase EZH2 and upregulated MST1, which suppressed YAP1, promoting M2 macrophage polarization and thereby, alleviating neural injury in hypercalcemia arising from renal failure.
View Article and Find Full Text PDFArticle Synopsis
- Integrated kidney care connects preventative measures for chronic kidney disease with health services for those already affected, focusing on smooth transitions between different stages of the disease and treatment options.
- Supportive care is crucial for individuals with kidney failure, yet it is often lacking or poorly integrated, particularly in low- and middle-income countries where resources are limited.
- The International Society of Nephrology has developed consensus definitions and guidelines to improve the understanding and implementation of conservative kidney management and supportive care in these under-resourced settings.